Polythea on Cordis and OpenAIRE


– Nidia Maldonado-Carmona – Acetylated lignin nanoparticles as a new photosensitizer’s vehicle for Photodynamic Antimicrobial Chemotherapy (PACT)

– Dáire J. Gibbons – Triplet state access in multi-component heavy atom free photosensitizers in photomedicine

– João Simões – Radiolabelled porphyrinic metalla-assemblies linked to cellulose nanocrystals as PDT and imaging agents

– Bhavya Khurana – Antimicrobial formulation and functionalization of photosensitizers for antimicrobial photodynamic therapy (aPDT)

– Manuel Gallardo-Villagrán – New anti-inflammatory and pro-apoptotic photosensitizers against arthritis and synovial sarcoma

– Zoi Melissari – Pyrrole-based Photosensitisers for Photomedicine. Synthesis, Photophysical and Photobiological Evaluation of Chlorins and Dipyrrin Complexes

– Piotr Gierlich – Covalently cross-linked tetrafunctionalized m-THPC chitosan hydrogels as drug delivery platforms



– G. Piccirillo, N. Maldonado-Carmona, D. L.Marques, N. Villandier, C. A. Calliste, S. Leroy-Lhez, M. Ermelinda, S.Eusébio, M.J.F.Calvete, M.M.PereiraPorphyrin@Lignin nanoparticles: Reusable photocatalysts for effective aqueous degradation of antibiotics, Science Direct, 2022, DOI: 10.1016/j.cattod.2022.09.009

P. Gierlich, L. Rodrigues, F. A. Schaberle, S. Callaghan, L. C. Gomes-Da-Silva, M. O. Senge, Trimethoxyphenyl-BIDOPYs as probes for lysosome staining, World Scientific, 2022, DOI: 10.1142/S1088424622500328 

– C. Donohoe, F. A. Schaberle, F. M. S. Rodrigues, N. P. F. Gonçalves, C.J. Kingsbury, M.M. Pereira, M.O. Senge, L.C. Gomes-da-Silva, L.G. ArnautUnraveling the Pivotal Role of Atropisomerism for Cellular Internalization, Journal of the American Chemical Society, 2022, DOI: 10.1021/jacs.2c05844

– M. Gallardo-Villagrán, L. Paulus, D. Y. Leger, B. Therrien, B.Liagre, Dimethyl Sulfoxide: A bio-friendly or bio-hazard chemical? The effect of DMSO in human fibroblast-like synoviocytes, Molecules, 2022, DOI: 10.3390/molecules27144472

– M. Gallardo-Villagrán, L. Paulus, J.-L. Charissoux, D. Y. Leger, P. Vergne-Salle, B. Therrien, B.Liagre, Ruthenium-based assemblies incorporating tetrapyridylporphyrin panels: a photosensitizer delivery strategy for the treatment of rheumatoid arthritis by photodynamic therapy, Dalton Transactions, 2022, DOI: 10.1039/d2dt00917j

– C. Donohoe, S. Leroy-Lhez, M. O. Senge and L. C. Gomes-da-Silva, POLYTHEA – The opportunities and challenges of doctoral training networks, Journal of Porphyrins and Phthalocyanines, 2022, DOI: 10.1142/S1088424622500250

– D. J. Gibbons, A. Boh, B. Habermeyer, N. Villandier, S. Leroy-Lhez, R. M. WilliamsPhoto-activated thin films of porphyrins for reactive oxygen species generation, Journal of Porphyrins and Phthalocyanines, 2022, DOI: 10.1142/S1088424622500183

– M. Gallardo-Villagrán, L. Paulus, Y. Champavier, D.Y. Leger, B. Therrien, B. Liagre, Combination of tetrapyridylporphyrins and arene ruthenium (II) complexes to treat synovial sarcoma by photodynamic therapy, J. Porphyrins Phthalocyanines 2022, DOI: 10.1142/S1088424622500018



– P. Gierlich, S.G. Mucha, E. Robbins, L. C. Gomes-da-Silva, K. Matczyszyn, M. O. Senge, One-Photon and Two-Photon Photophysical Properties of Tetrafunctionalized 5,10,15,20-tetrakis(m-hydroxyphenyl)chlorin (Temoporfin) Derivatives as Potential Two-Photon-Induced Photodynamic Therapy Agents, Chemistry Europe, 2021, doi: 10.1002/cptc.202100249

– M. Gallardo-Villagrán, L. Paulus, J-L Charissoux, S. Sutour, P. Vergne-Salle, D.Y. Leger, B. Liagre, B. Therrien,  Evaluation of Ruthenium-Based Assemblies as Carriers of Photosensitizers to Treat Rheumatoid Arthritis by Photodynamic TherapyPharmaceutics. 2021, 13, 2104. doi.org/10.3390/pharmaceutics13122104

S. Bisserar, D.M.E.V Raamsdonk, D.J. Gibbons, R.M. WilliamsSpin Orbit Coupling in Orthogonal Charge Transfer States: (TD-)DFT of Pyrene – Dimethylaniline. Preprints 2021, 2021120109, doi: 10.20944/preprints202112.0109.v1

 N. Maldonado-Carmona, T-S. Ouk, N. Villandier, C. A. Calliste, M.J.F. Calvete, M.M. Pereira and S. Leroy-Lhez, Photophysical and Antibacterial Properties of Porphyrins Encapsulated inside Acetylated Lignin Nanoparticles, Antibiotics, 2021, https://doi.org/10.3390/antibiotics10050513

– K. Norvaisa, S. Maguire, C. Donohoe, J.E. O’Brien, B. Twamley, L.C. Gomes-da-Silva, M.O. Senge, Steric Repulsion Induced Conformational Switch in Supramolecular Structures, Chemistry A European Journal, 2021, https://doi.org/10.1002/chem.202103879

– N. Maldonado‑Carmona, T.‑S. Ouk, S. Leroy‑LhezLatest trends on photodynamic disinfection of Gram‑negative bacteria: photosensitizer’s structure and delivery systems, Photochemical & Photobiological Sciences, 2021, https://doi.org/10.1007/s43630-021-00128-5

– E. Robbins, S. Leroy-Lhez, N. Villandier, M. Samoć, K. Matczyszyn. Prospects for More Efficient Multi-Photon Absorption Photosensitizers Exhibiting Both Reactive Oxygen Species Generation and Luminescence Molecules 26, no. 20: 6323, 2021. https://doi.org/10.3390/molecules26206323 

– Z. Melissari, R.M. Williams, M.O. Senge, Porphyrinoids for Photodynamic Therapy, Royal Society of Chemistry, 2021, DOI: 10.1039/9781839164149-00252

– H. C. Sample, G. Emandi, B. Twamley, N.Grover, B. Khurana, V. Sol, M.O. SengeSynthesis and Properties of BODIPY Appended Tetraphenylethylene Scaffolds as Photoactive Arrays, European Journal of Organic Chemistry, 2021, DOI: 10.1002/ejoc.202100629

– J. Godard, D. Gibbons, S. Leroy-Lhez, R.M. Williams, N. Villandier, T.S. Ouk, F. Brégier, V. Sol, Development of Phenalenone-Triazolium Salt Derivatives for aPDT: Synthesis and Antibacterial Screening, Antibiotics, 2021, DOI : 10.3390/antibiotics10060626

– K.J. Flanagan, M.P. Dominguez, Z. Melissari, H.G Eckhardt, R.M. Williams, D. Gibbons, C. Prior, G.M. Locke, A. Meindi, A.A. Ryan and M.O. SengeStructural Effects of meso-Halogenation on Porphyrins: meso-Xn-ABCD Macrocycles, Beilstein Archives, 2021, DOI: https://doi.org/10.3762/bxiv.2021.21.v1

– C.J. Kingsbury, H.C. Sample, M.O. SengeCrystal structures of 4-bromo-2-formyl-1-tosyl-1H-pyrrole, (E)-4-bromo-2-(2-nitro­vin­yl)-1-tosyl-1H-pyrrole and 6-(4-bromo-1-tosyl­pyrrol-2-yl)-4,4-di­methyl-5-nitro­hexan-2-one, Crystallographic Communications, 2021, Crystallographic Communications, DOI: 10.1107/S2056989021002280



– N. Maldonado-Carmona, G. Marchand, N. Villandier, T. S. Ouk, M.M. Pereira, C.A. Calliste, A. Zak, M. Piksa, K.J. Pawlik, K. Matczyszyn, S. Leroy-Lhez, Porphyrin-Loaded Lignin Nanoparticles Aglainst Bacteria: A Photodynamic Antimicrobial Chemotherapy Application, Frontiers in Microbiology, 2020, DOI: 10.3389/fmicb.2020.606185

B.F. Hohlfeld, B. Giter, C.J. Kingsbury, K.J. Flanagan, D. Steen, G.D. Wieland, N. Kulak, M.O. Senge, A. Wiehe, Dipyrrinato-Iridium (III) Complexes for an Application in Photodynamic Therapy and Antimicrobial Photodynamic Inactivation, Chemistry Europe Journal, 2020, DOI: 10.1002/chem.202004776

– P. Gierlich, A.I. Mata, C. Donohoe, R.M.M Brito, M.O. Senge, L.C. Gomes-da-Silva, Ligand-tageted delivery of photosensitizers for cancer treatment, MDPI, 2020, DOI: 10.3390/molecules25225317

– J.C.S Simões, S. Sarpaki, P. Papadimitroulas, B. Therrien, G. Loudos, Conjugated Photosensitizers for Imaging and PDT in Cancer Research, American Chemical Society Publications, 2020, DOI: 10.1021/acs.jmedchem.0c00047

G. Marchand, G. Fabre, N. Maldonado-Carmona, N. Villandier, S. Leroy-Lhez, Acetylated lignin nanoparticles as a possible vehicle for photosensitizing molecules, Royal Society of Chemistry, 2020, DOI: 10.1039/D0NA00615G

– H. C. Sample, M.O. Senge, Nucleophilic Aromatic Substitution (SNAr) and Related Reactions of Porphyrinoids: Mechanistic and Regiochemical Aspects, European Journal of Organic Chemistry, 2020, DOI: 10.1002/ejoc.202001183

– N. Grover, G. Emandi, B. Twamley, B. Khurana, V. Sol, M.O. Senge, Synthesis and structure of meso-Substituted |20π] – Dibenzihomoporphyrins, European Journal of Organic Chemistry, 2020, DOI: https://doi.org/10.1002/ejoc.202001165

– Z. Melissari, H.C. Sample, B. Twamley, R.M. Williams, M.O. Senge, Synthesis and spectral properties of Gem– dimethyl chlorin photosensitizers, Chemistry Europe, 2020, DOI:10.1002/cptc.202000051

– N. Maldonado-Carmona, T.S. Ouk, M.J.F. Calvete, M.M. Pereira, N. Villandier, S. Leroy-Lhez, Conjugating biometerials with photosensitizers: advances and perspectives for Photodynamic Antimicrobial Chemotherapy, Photochemical & Photobiological Sciences, 2020, DOI: 10.1039/C9PP00398C 

D. J. Gibbons, A. Farawar, P. Mazella, S. Leroy-Lhez, R. M. Williams, Making triplets from photo-generated charges: observations, mechanisms and theory, Photochemical & photobiological sciences, 2020, DOI: 10.1039/C9PP00399A 



 C. Lian, M. Piksa, K. Yoshida, S. Persheyev, K. J. Pawlik, K. Matczyszyn, I. D. W. Samuel, Flexible organic light-emitting diodes for antimicrobial photodynamic therapy, 3, article 18,  2019. DOI: 10.1038/s41528-019-0058-0

– A. Wiehe, J. O’Brien, M.O. SengeTrends and targets in antiviral phototherapy, Photochemical & Photobiological Sciences 21, 2565-2612, 2019, DOI: 10.1039/C9PP00211A

– L. M. Mazur, T. J. Roland, S. Leroy-Lhez, V. Sol, M. Samoc, I. D.W. Samuel, K. Matczyszyn, Efficient Singlet Oxygen Photogeneration by Zinc Porphyrin-Dimers Upon One- and Two-Photon ExcitationThe journal of Physicall Chemistry, 2019, DOI: 10.1021/acs.jpcb.8b12561

– C. Donohoe, M. O.Senge, L. G. Arnaut and L. C.Gomes-da-Silva, Cell death in photodynamic therapy: From oxidative stress to anti-tumor immunityBiochimica et Biophysica Acta (BBA) – Reviews on Cancer,  2019, DOI: 10.1016/j.bbcan.2019.07.003 

– B. Khurana, P. Gierlich, A. Meindl, L. C. Gomes-da-Silva and M. O. SengeHydrogels: soft matters in photomedicine Photochemical & Photobiological Sciences, 2019, DOI: 10.1039/C9PP00221A

M. Gallardo-Villagran, D.Y. Léger, B. Liagre, B. TherrienPhotosensitizers used in the Photodynamic Therapy of Rheumatoid Arthritis, International Journal of Molecular Sciences, 2019, 20, 3390. DOI: 10.3390/ijms20133339

– B.F. Hohlfeld, K. J. Flanagan, N. Kulak, M. O. Senge, M. Christmann, A. WieheSynthesis of Porphyrinoids, BODIPYs and (Dipyrrinato)ruthenium(II) Complexes from Pre‐functionalized Dipyrromethanes, European Journal of Organic Chemistry, 2019 – DOI: 10.1002/ejoc.201900530



–  B. TherrienThe Role of second coordination sphere in the biological activity of arene ruthenium metalla-assemblie, Frontiers in Chemistry,  2018, 6, Article 602 – DOI: 10.3389/fchem.2018.00602

– C. S. Gutsche, S. Gräfe, B. Gitter, K. J. Flanagan, M. O. Senge, N. Kulak and A. Wiehe, Pre-/post-functionalization in dipyrrin metal complexes – antitumor and antibacterial activity of their glycosylated derivativesDalton Transactions, 2018, DOI:10.1039/C8DT03059F

– G. Marchand, C. A. Calliste, R. M. Williams, C. McLure, S. Leroy-Lhez and N. Villandier, Acetylated Lignins: A Potential Bio-Sourced PhotosensitizerChemistrySelect, 2018, DOI:10.1002/slct.201801039

– Susan Callaghan and Mathias O. SengeThe good, the bad, and the ugly – controlling singlet oxygen through design of photosensitizers and delivery systems for photodynamic therapy,  Photochemical & Photobiological Sciences, 2018, DOI: 10.1039/C8PP00008E