Project title: Formulation of photo-sensitizers for antimicrobial applications

Employer: University of Limoges (UNILIM, France), Cotutelle: Trinity College of Dublin (TCD, Ireland)
Supervisors: Pr Vincent SOL (UNILIM), Prof Dr. Mathias O. SENGE (TCD)

Research secondments: INSERM (UMR 1092, Limoges), Biolitec
Practical rotation: Selvita

Research project description and main objectives: One main issue of the POLYTHEA project is to develop photosensitizing dyes and their formulations which can be used in a modular fashion for a variety of biomedical applications particularly for antimicrobial applications within the consortium.

This project will focus on the design, synthesis of photosensitizers (PS) and their different  formulations (with polymers, biopolymers,…) for antimicrobial applications. The best polymers/PS pair will be selected on the basis of photodynamic properties, biocompatibility and stability of bactericidal material, PS repartition in the formulation and in vitro bactericidal effect on planktonic bacteria cells or on bacterial biofilm.
The main objective of this project is providing new formulations of PS, which will allow practical application in various fields such as food safety, self-sterilizing surface, medical materials. Moreover, this study will afford further insight into the photodynamic process of bacteria killing.

The project is divided into three parts:
1)      Design, synthesis and characterizations of PS for photodynamic therapy antimicrobial applications
2)      Formulation and characterization of these PS/polymers complexes
3)      Microbiological evaluation of these formulations against planktonic bacterial cells and bacterial biofilm.

This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement n°764837