João SIMOES



Project title: Using cellulose nanocrystal (CNC) as multi-purpose platform

Employer: BET Solutions (Greece), Cotutelle: University of Neuchâtel (UNINE, Switzerland)
Supervisors: Pr George Loudos (BET), Pr Bruno Therrien (UNINE), Dr. Katarzyna Matczyszyn (PWR)

Research secondments: Politechnika Wroclawska (PWR), University of Limoges, Biolitec
Practical rotation: Selvita

Research project description and main objectives: At the forefront of chemistry, nano-materials and biology, this project intends to use cellulose nanocrystals to transport and deliver photo-responsive molecules to biological targets. Four main objectives are foreseen: a) to prepare and characterize cellulose nanocrystals as well as b) photo-responsive molecules; c) to load the nanocrystals with the photo-responsive compounds, and; d) to evaluate the biological potential of the newly developed nano-carriers in in vitro and in vivo models. To achieve these goals, the candidate will have to use synthetic organic strategies to functionalize the photo-responsive molecules in view of grafting them to the nanocrystals, and to learn radio-labelling techniques to optimize visualization and to identify biological targets. Being a multidisciplinary project, the candidate will need to be able to work independently, to possess excellent collaborative skills, and to adapt rapidly to different scientific environments

This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement n°764837